Biological Homeostasis

Effect of an Antagonist of Vasoactive Intestinal Polypeptide on Biological Rhythm of Rest Activity in the Rat

Abstract Vasoactive Intestinal Polypeptide (VIP), has been found in different neurotransmitter systems and exists in various nerve tracts in the brain. Potential role of this peptide in physiological processes such as regulation of sleep and wakefulness, and biological rhythms has been confirmed in several reports. In the present research effects of intracerebroventricular (ICV) injection of a...

Genome-wide Association Study to Identify Genes and Biological Pathways Associated with Type Traits in Cattle using Pathway Analysis

Extended Abstract Introduction and Objective: Type traits describing the skeletal characteristics of an animal are moderately to strongly genetically correlate with other economically important traits in cattle including fertility, longevity and carcass traits. The present study aimed to conduct a genome wide association studies (GWAS) based on gene-set enrichment analysis for identifying the ...

Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies

Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’  role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...

Understanding copper homeostasis in humans and copper effects on health.

Integral Control Feedback Circuit for the Reactivation of Malfunctioning p53 Pathway

Many biological systems inherently possess the natural ability to adapt to environmental changes in order to maintain survivability. This ability of a biological system’s sensory adaptation give rise to homeostasis. There has been numerous report of homeostasis of biological systems such as heat shock proteins, glucose level and bile acid level regulations (1–4). In responding to external pertu...